Heathcote Road is closed in both directions at Engadine due to truck and car crash approximately one kilometre west of Forum Drive.
Motorists are advised to avoid the area and divert via Princes Highway, The Grand Parade, Linden Street, River Road, Bangor Bypass and New Illawarra Road in both directions.
Motorists should also allow extra travel time.
Emergency services and traffic crews are responding.
For the latest traffic information, download the Live Traffic NSW app, visit www.livetraffic.com or call 132 701.